Polyurethane (PU) enameled wire is an important variety in enameled wire products due to its direct solderability and hydrolysis resistance. The development of PU-enameled wire with a low friction coefficient is the guarantee of ultrahigh processing speed and the long life of high-end electronic and electrical coils. Although there are many research reports on polyurethane coatings, the friction coefficient of polyurethane wire enamels is still decreased by coating with paraffin wax, which is forbidden for components of high-end electronic and electrical products. Therefore, the introduction of fluorine-containing groups in the PU molecule chain will be a key to develop low friction coefficient PU-enameled wires without coating with paraffin lubricants. Tonelli et al. reported the lowest friction coefficient of 0.28 for fluorine-containing thermoplastic polyurethanes prepared by a three-step polymerization technique using poly(tetramethylene glycol), polybutadienediol, poly(fluorooxyalkylene) diol, and diisocyanate (MDI) as starting materials and 1,4-butanediol as a chain extender. Li et al. blended thermoplastic polyurethanes with fluorinated ultrahigh-molecular-weight polyethylene to obtain the composite with the friction coefficient of 0.19. The lowered friction coefficient was attributed to the low surface free energy of fluorine-containing groups. In this paper, the fluorine element was introduced into the polyurethane main chain by a simple two-step method using perfluoropolyether polyol, poly(propylene glycol) (PPG), and isophorone diisocyanate (IPDI) as starting materials and 1,4-butanediol as a chain extender. The lowest friction coefficient of 0.095 for fluorinated polyurethane-enameled wires was obtained. Therefore, it is of great significance to the development of high-end electronic devices.